Users Online : 1068 About us |  Subscribe |  e-Alerts  | Feedback | Login   |   
Journal of Minimal Access Surgery Current Issue | Archives | Ahead Of Print Journal of Minimal Access Surgery
           Print this page Email this page   Small font sizeDefault font sizeIncrease font size 
 
ORIGINAL ARTICLE
Ahead of Print

Prognosis of laparoscopic surgery for colorectal cancer in middle-aged patients


 Department of General Surgery, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, China

Correspondence Address:
Jian-Ying Shang,
Department of General Surgery, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, 12 Changjia Lane, Jingzhong Street, Mianyang, 621000, Sichuan
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jmas.jmas_81_22

PMID: 35915539

Background: The prognosis of middle-aged patients with colorectal cancer (CRC) treated by laparoscopic resection (LR) is unclear. This study aimed to evaluate the survival outcomes of LR compared with open resection (OR) for middle-aged patients with CRC. Patients and Methods: This retrospective cohort study used the data from a database of all consecutive colorectal resections performed between January 2009 and December 2017. Propensity score matching (PSM) was performed to handle the selection bias based on age, gender, body mass index, tumour location, AJCC stage and admission year. Univariate and multivariate COX regression model was used to identify risk factors of overall survival (OS) and disease-free survival (DFS). Results: After PSM, 154 patients were included in each group. Compared with the OR group in the total cohort, there were better survival outcomes in the LR group for 5-year OS and 5-year DFS (both P < 0.001). These differences were observed for Stage II and III diseases and for all CRC, irrespective of location. The multivariate analysis showed that tumour ≥5 cm (hazard ratio [HR] = 1.750, 95% confidence interval [CI]: 1.026–2.986, P = 0.040), Stage III (HR = 14.092, 95% CI: 1.894–104.848, P = 0.010) and LR (HR = 0.300, 95% CI: 0.160–0.560, P < 0.001) were independently associated with OS. Pre-operative carcinoembryonic antigen ≥5 ng/ml (HR = 3.954, 95% CI: 1.363–11.473, P = 0.011), Stage III (HR = 6.206, 95% CI: 1.470–26.200, P = 0.013) and LR (HR = 0.341, 95% CI: 0.178–0.653, P = 0.001) were independently associated with DFS. Conclusions: In middle-aged patients with CRC, LR achieves better survival than OR. Complications are similar, except for less blood loss and shorter post-surgical hospital stay with LR.


Print this article
Search
 Back
 
  Search Pubmed for
 
    -  Bao F
    -  Wu LR
    -  Deng ZG
    -  Xiang CH
    -  Shang JY
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed249    
    PDF Downloaded3    

Recommend this journal

2004 Journal of Minimal Access Surgery
Published by Wolters Kluwer - Medknow
Online since 15th August '04