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Year : 2005  |  Volume : 1  |  Issue : 3  |  Page : 136

Menetrier's disease with gastrointestinal bleed

Department of Surgery, Subham Hospital and Diagnostic Centre, Cooch Behar - 736101, West Bengal, India

Correspondence Address:
Kaushik Bhattacharya
A-5,208 HIG TNHB Flats, Anna Main Road, K.K.Nagar(W), Chennai - 600078
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-9941.18999

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How to cite this article:
Bhattacharya K. Menetrier's disease with gastrointestinal bleed. J Min Access Surg 2005;1:136

How to cite this URL:
Bhattacharya K. Menetrier's disease with gastrointestinal bleed. J Min Access Surg [serial online] 2005 [cited 2022 Sep 27];1:136. Available from:

A 22-year-old male presented with recurrent upper gastrointestinal bleeding along with pain in the abdomen. An upper gastrointestinal endoscopy revealed Menetrier's disease affecting the body of the stomach, which was confirmed histopathologically [Figure - 1]. There was hyperplasia of foveolar cells with elongation of the crypts, decrease in the number of gastric glands and mild lymphocytic infiltration within the lamina propria [Figure - 2]. No endoscopic ultrasound was done in this patient due to its nonavailability. Menetrier's disease is a rare premalignant disorder of the stomach generally described as hypertrophic gastropathy associated with hypoproteinemia and achlorhydria. This disease is characterized by excessive mucous secretion, but differs little from normal stomach with regards to the types of mucin produced.[1] Gastric resection is still the most definitive treatment for the disease, but the appropriate extent of resection has not been determined.[2] The condition should be distinguished from hyper-rugosity of the gastric mucosa in which there is no protein and hyper-rugosity, which may be associated with Zollinger Ellison syndrome, malignancy, infectious diseases (cytomegalovirus, histoplasmosis, syphilis) and infiltrative diseases like sarcoidosis.

  References Top

1.Mall AS, Taylor K, Barnard R, Dent DM, Kahn D. Expression of gastric mucin in the stomachs of two patients with Menetrier's disease: an immunohistochemical study. J Gastroenterol Hepatol 2003;18:876-9.  Back to cited text no. 1    
2.Kim J, Cheong JH, Chen J, Hyung WJ, Choi SH, Noh SH. Menetrier's disease in Korea: report of two cases and review of cases in a gastric cancer prevalent region. Yonsei Med J 2004;45:555-60.  Back to cited text no. 2    


[Figure - 1], [Figure - 2]


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2004 Journal of Minimal Access Surgery
Published by Wolters Kluwer - Medknow
Online since 15th August '04